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preclinical study dataset...okines on DC in vivo. Our investigation has shown that, in the absence of additional stimuli, such inflammatory signals are ineffectual in promoting DC activation and cannot substitute for engagement of innate receptors directly on DC.
- cell type: T cell
- cell type: dendritic cell
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transcriptomic dataset...nct and restricted sets of cell surface markers and functional parameters. We obtained coexpression data of 18 genes simultaneously in individual cells from CD8+ T cell subsets (associated to multiple markers to subdivide CD8+ T cells into 14 different cell types, several of which were not describ...
- cell type: T cell
- cell type: dendritic cell
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preclinical study dataset...her functional activation of human monocyte-derived DCs can be achieved by electroporation of an activation signal in the form of double-stranded (ds) RNA and whether simultaneous electroporation of the dsRNA with tumor antigen encoding mRNA can lead to the induction of a cytotoxic T-lymphocyte (CTL...
- cell type: cytotoxic T lymphocyte
- cell type: immature dendritic cell
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preclinical study dataset... antigen-specific CD8+ T lymphocytes. In addition, CD83 mRNA-electroporated DC are stronger T cell stimulators. However, CD83 overexpression on Melan-A/MART-1-specific tumor-infiltrating lymphocytes (TIL) circumvents the need for CD83 expression on DC. Co-culture of immature DC with TIL or K562 cell...
- cell line type: K562 cell line
- cell type: memory B cell
- cell type: mature dendritic cell
- cell type: immature dendritic cell
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preclinical study dataset...ure monocyte-derived dendritic cells after transduction with high doses of lentiviral vectors. Dendritic cells (DCs) are an attractive tool for immunomodulation, targeting mature DCs (mDCs) for immunization or immature/semimature DCs (iDCs) for tolerization. Therefore, introducing antigens into DC...
- cell type: immature dendritic cell
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preclinical study dataset...tigen (Ag) to deliver its cargo to endosomes of murine Dendritic cells (DCs), thus initiating TLR mediated DC maturation as well as processing of MHC class I and class II restricted epitopes. In these studies we used as Ag either Ovalbumin, or rec. Prion-protein. In the latter system, a CD4 T cell...
- cell type: T cell
- cell type: dendritic cell
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preclinical study dataset...ained data on the role of p50 NF-kB in differentiation, survival and APC function in mice. Tumor growth is supported by tumor stroma, which is made by matrix and infiltrating cells, such as tumor associated macrophages (TAM) and tumor associated dendritic cells (TADC). We have recently reported tha...
- cell type: T cell
- cell type: dendritic cell
- cell type: macrophage
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preclinical study dataset...is a an important topic as sites of inflammation are often characterized by both low oxygen tension and an extensive infiltration of inflammatory leukocytes, including DC, which need to move against oxygen gradients. We showed that oxygen availability is necessary to promote full monocyte-derived DC...
- cell type: T cell
- cell type: dendritic cell
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Studies of rat DC migration and activation in response to TLR agonists in relation to oral adjuvantspreclinical study dataset...uses massive changes in DC migration and leads to their activation in lymph nodes but not lymph. These changes are due to TNF-alpha (migration) and Type 1 interferons (activation), but are not accompanied by obvious oral adjuvant effects. In contrast Etx causes only minor changes in migration and ac...
- cell type: dendritic cell
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preclinical study dataset...ctivation of naïve and memory T cells in rats. We have shown that two of the three DC subsets are highly potent activators of naïve CD4+ T cells, and do not appear to be constitutively suppressed in any way. We are currently examining the phenotype of the activated cells and determining if Treg...
- stimulus type: dendritic cell
- cell type: memory T cell
- cell type: regulatory t cell
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preclinical study dataset...intestinal denritic cells are not constitutively biased towards stimluating Th2 responses (Milling). We have shown that antigen given orally during intestinal inflammation stimulates a strong response rather than tolerance.(Sebti). We have clarified the roles of dendritic cells and regulatory T cell...
- cell type: dendritic cell
- cell type: T helper cell 2
- cell type: regulatory t cell
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preclinical study dataset...ted by activated iNKT cells (Hermans et al, 2007). DC maturation induced in vivo with any one of a variety of TLR ligands was greatly improved through simultaneous administration of the iNKT cell ligand alpha-galactosylceramide. DC isolated from animals treated simultaneously with TLR and iNKT cell...
- cell type: T cell
- cell type: B cell
- stimulus type: dendritic cell
- cell type: lymphocyte
- cell type: iNKT cell
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clinical study datasetWe have obtained data from an analysis of antigen loading of DCs via targeting DC-SIGN, which resulted in enhanced class II-mediated presentation. Constructs for fusion proteins of the DC specific receptor DC-SIGN fused to GFP have been generated.
- cell type: dendritic cell
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preclinical study datasetOur lab obtained data on maturation of DC by TLR agonists.
- cell type: dendritic cell
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preclinical study dataset...from the endosomal into the cytosolic compartment by combining antigen with cell penetrating peptides to further enhance cross-presentation. We made significant progress using biodegradable polymers to enhance cross-presentation of loaded antigens, and the best results were obtained by maturing DC...
- cell type: dendritic cell
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preclinical study dataset.../O and mutant mouse strains. Cross presentation is the process by which Dendritic cells (DC) phagocytose pathogens or dying cell fragments, and present proteolytic peptides derived from these antigens in association with MHC class I molecules. The reasons why DCs are the only antigen presenting cell...
- cell type: dendritic cell
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preclinical study dataset...ence of TGF-beta during lactation and was mediated by regulatory CD4+ T lymphocytes. Adoptive transfer experiments of LACK-specific TCR transgenic T cells into newborn mice breastfed by LACK-exposed mothers demonstrated that LACK was readily processed and presented to T cells in the neonate. We the...
- cell type: T cell
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transcriptomic dataset...om studies of CD8 T cell properties in man comparing HIV, CMV and EBV-specific cells. It is usually assumed that effector gene expression in CD8 T cells may be similar in all immune responses, CD8 T cells in vivo differentiating into cytotoxic T cells that also produce g-inf. In contrast we publis...
- cell type: T cell
- cell type: cytotoxic T lymphocyte
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clinical study dataset...unraveled the bioactivity of Dex onto NK cells, Dex promoting a IL-15Ra-dependent NK cell proliferation and a NKG2D-dependent activation resulting in an anti-metastatic effect. In humans, Dex bear functional IL-15R? which allow proliferation and IFNg secretion by NK cells. In contrast to immature DC...
- cell line type: K562 cell line
- cell type: T cell
- cell type: dendritic cell
- cell type: natural killer cell
- cell type: autologous natural killer cell
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preclinical study dataset... of intracellular pathogens to limit host immune pathology. IL-10 has been shown to exert its suppressive effect by directly acting on the antigen presenting cell (APC), therefore functioning to down-regulate macrophage antimicrobial activity or the induction of Th1 responses by dendritic cells (DC...
- cell type: T cell
- cell type: dendritic cell
- cell type: T helper cell 1
- cell type: macrophage