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signalling dataset...-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by TLR agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production, it is therefore plausible that the stimulation of TLRs on DCs may lead to activation of the C...
- cell type: dendritic cell
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signalling dataset...esence of TLR stimuli able to induce Th1 responses STAT-1 was activated. This observation strongly suggested that the molecules selectively produced by DC in presence of Th1 stimuli and not in presence of Th2 stimuli were type I IFNs and that these cytokines were presumably required for NK cell acti...
- cell type: dendritic cell
- stimulus type: T helper cell 1
- stimulus type: T helper cell 2
- cell type: natural killer cell
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signalling dataset...mmunophenotype, the antigen up-take activity, the secretion of cytokines/chemokines, and the ability of silenced MDDCs to stimulate T cell allogenic proliferation in classical MLR assays. No consistent and reproducible differences in the immunophenotype and antigene uptake capability of both iMDDC...
- cell type: dendritic cell
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signalling dataset... fide signalling pathway from a cell surface innate receptor other than a TLR. We will continue to study innate signalling pathways in dendritic cells. Our focus will be on TLR-independent signalling pathways involved in viral recognition, including RIG-I and MDA5, as well as signalling via C-type...
- cell type: dendritic cell
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preclinical study dataset...ed on the recruitment of distinct subsets of DC to skin. This work, which is being performed in collaboration with PowderMed, a former SME now owned by Pfizer, may lead to the development of more targeted strategies to induce distinct T cell responses using this technology. A publication has resulte...
- cell type: T cell
- cell type: dendritic cell
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signalling dataset... DC by Toll like receptor ligands (TLR-L) that modulates the lipid biosynthetic pathway, resulting in enhanced recognition of CD1d-associated lipids by iNKT cells. DC derived soluble factors further increase CD1d-restricted iNKT cell activation, as defined by IFN-alpha secretion. Finally, using solu...
- cell type: dendritic cell
- cell type: iNKT cell
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preclinical study dataset... the role of ICOShi regulatory T cells in the intestine in steady state conditions and (3) the role of intestinal flora in the development of these cells using axenic mice. In parallel, we are testing whether the population of natural regulatory T cells (CD25+) control immune responses by acting on ...
- cell type: T helper cell 1
- cell type: ICOShi regulatory T cell
- cell type: natural regulatory T cell (CD25+)
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preclinical study datasetOur laboratory has obtained data on the role of DC-derived cytokines in NK cell production of IFN-gamma.
- cell type: natural killer cell
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signalling dataset...lity at inducing T cell activation. Indeed we established that the mDC/pDC cross-talk has a functional effect on T cell activation. In fact the mDC/pDC cooperation event is able to significantly increase the ability of these cells to drive the proliferation and IFN? production by alloreactive T cell...
- cell type: T cell
- cell type: myeloid dendritic cell
- cell type: plasmacytoid dendritic cell
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preclinical study dataset...co-cultured pDC. On the other hand type I interferons produced by CpG-activated pDCs is required for activation of the mDC. We also observed a strong synergistic response of both cell types, using limiting conditions of stimulus on co-cultured mDCs and pDCs. The study on the response of human MoDC...
- cell type: spore
- cell type: spheroplast
- cell type: myeloid dendritic cell
- cell type: plasmacytoid dendritic cell
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preclinical study datasetOur lab has obtained data on maturation stimuli for GMP-grade DC.
- cell type: dendritic cell
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preclinical study dataset...ur lab has generated data on receptors on dendritic cells necessary for capture of exosomes. In 2007, we have finalized analysis of the receptors on DCs responsible for capture of exosomes secreted by mature DCs. We have shown that expression of LFA-1, but not of Mac-1, integrin, on DCs is required ...
- cell type: mature dendritic cell
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preclinical study dataset...ained data from a study where we addressed a model antigen to exosomes secreted by tumor cells in vivo, to allow capture of antigen-bearing exosomes by DCs and cross-presentation of the antigen. For this purpose, the model antigen OVA was fused to the C1C2 exosome-binding domain of MFG-E8/lactadheri...
- cell type: T cell
- cell type: natural killer cell
- cell type: tumor cell
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signalling dataset...ween human monocyte derived DCs (MDDC), generated in the presence of GM-CSF and IL-4 (IL-4 DC), and antigen-stimulated circulating gamma delta T lymphocytes, bearing the Vgamma2 TCR. Co-cultures of IFN-DCs with zoledronate-stimulated gamma delta T lymphocytes were also performed. gamma delta T-cell ...
- cell type: gamma-delta t cell
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preclinical study dataset...bLf, whose immunomodulant properties are now recognized, on MDDC differentiation/activation. We found that bLF interferes with the activation of MD-DC induced by different TLR agonists, but not by T cell mediated signals. Although bLF did not significantly influence monocyte differentiation in DCs,...
- cell type: T cell
- cell type: T helper cell 1
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preclinical study dataset...regulatory mechanism evolved to maintain immunological balance (Del CornĂ² et al.). Future studies will focus on - characterizing the mechanism(s) by which cross-tolerance between TLRs induce different functional states of DCs that favour different T cell effector phenotypes. Moreover, a further c...
- cell type: dendritic cell
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preclinical study dataset...of both cell populations will be performed, and in particular it will be analyzed: (a) the capacity of virus-exposed DCs to recruit resting gamma-delta T cells; (b) the role of activated lymphocytes in controlling HIV-1 replication in DCs; (c) whether active virus replication in these cells is ne...
- cell type: gamma-delta t cell
- cell type: immature dendritic cell
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preclinical study dataset...t CTL expansion, effector function and CTL memory. In contrast, CTL that have received suboptimal stimulation fail to undergo extensive expansion. Nevertheless these arrested CTL persist long term and acquire memory function in the absence of further cell division. Thus our data demonstrate that CTL...
- cell type: cytotoxic T lymphocyte
- cell type: OT1 cell
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preclinical study dataset...he way antigens should be introduced in DCs and how long after stimulation they should be used during vaccination application. We have also initiated studies on the impact of dsRNA on the regulation of translation and the functional response of DCs (IFN production). We have now demonstrated that DC...
- cell type: immature dendritic cell
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preclinical study dataset... TLR9. We will continue to use DC activation in vitro and, in particular, DC cytokine production as an assay to dissect innate pathways involved in DC activation. In parallel, we will continue to compare effector T cell instruction by DC activated via distinct innate receptors.
- cell type: T cell
- cell type: dendritic cell
- molecule type: regulatory t cell