Activation of DC by TLR agonists

Our lab gathered data on DC activation by pathogen-derived stimuli. We focused on the study of the response of MDDCs to the combined stimulation with TLR ligands and we observed that simultaneous activation of TLR4 and TLR8 signaling cascades results in a marked inhibition of the secretion of the proinflammatory chemokine CCL2 with respect to stimulation through a single TLR. This inhibition is specific for both CCL2 and TLR agonist combination and could represent a novel regulatory mechanism evolved to maintain immunological balance (Del Cornò et al.).

Future studies will focus on
- characterizing the mechanism(s) by which cross-tolerance between TLRs induce different functional states of DCs that favour different T cell effector phenotypes. Moreover, a further characterization of the molecular mechanisms underlying CCL2 regulation, will be also performed;
- defining the role of selected miR on the differentiation/activation of MDDCs.

• stimulus type
• TLR ligand

• molecule type
• Chemokine (C-C motif) ligand 2,
• Toll like receptor 4,
• Toll like receptor 8

• cell type
• dendritic cell

• experimental design type
• stimulus or stress response experiment

• experimental factor type
• Stimulation by molecular entity factor

created over 16 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]