Definition of novel innate signalling pathway in DC via dectin-1

We have data on a novel innate signalling pathway in DC. Using curdlan as a specific agonist of dectin-1, we have shown that this C-type lectin couple to Syk kinase leads to activation of ERK, JNK and p38 MAPKs, as well as NF-kappaB. However, signalling terminates rapidly once the receptor is internalised, thereby explaining previous observations that large, non-phagocytisable Dectin-1 ligands are much more potent agonists than smaller ones.

This is the first example of a bona fide signalling pathway from a cell surface innate receptor other than a TLR.

We will continue to study innate signalling pathways in dendritic cells. Our focus will be on TLR-independent signalling pathways involved in viral recognition, including RIG-I and MDA5, as well as signalling via C-type lectins related to Dectin-1, such as Dectin-2 and DNGR-1.

• molecule type
• c-jun N-terminal kinases,
• p38 MAPK,
• Extracellular signal-regulated kinase ERK,
• Nuclear factor NF-kappa B,
• curdlan,
• syk kinase,
• DEC receptor

• cell type
• dendritic cell

• experimental design type
• stimulus or stress response experiment

• stimulus type
• curdlan

created over 16 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]