Use of nano-particles for intestinal vaccine delivery

Data have been obtained on the use of nano-particles for intestinal vaccine delivery from our continued investigation of the use of nano-particles as oral vaccine vehicles (Cerovic). We have identified an important role for complement C1q in the uptake of scrapie agent by dendritic cells (Flores-Langarica).We have shown that a protein from Schistosomes has dramatic effects on intestinal physiology, including dendritic cells (Nassar). We have shown that steady-state intestinal denritic cells are not constitutively biased towards stimluating Th2 responses (Milling). We have shown that antigen given orally during intestinal inflammation stimulates a strong response rather than tolerance.(Sebti). We have clarified the roles of dendritic cells and regulatory T cells in a Th2-biased inflammatory bowel disease (McDonald).

• organ type
• intestine

• molecule type
• nanoparticle

• cell type
• dendritic cell,
• T helper cell 2,
• regulatory t cell

• organism type
• Schistosoma

• experimental design type
• compound treatment design experiment

created over 15 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]