Roles of rat DC subsets in activation of naïve and memory T cells and Tregs

Data have been obtained defining the differential roles of intestinal lymph DC subsets in activation of naïve and memory T cells in rats. We have shown that two of the three DC subsets are highly potent activators of naïve CD4+ T cells, and do not appear to be constitutively suppressed in any way.

We are currently examining the phenotype of the activated cells and determining if Tregs are induced. We have initiated (in collaboration with Pfizer) a study of nano-particles as potential deliverers of intestinal vaccines.

• stimulus type
• dendritic cell

• molecule type
• CD4

• cell type
• memory T cell,
• regulatory t cell

• organism type
• Rat

• organ type
• intestine

• experimental factor type
• Cell type factor

created over 16 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]