Effects of LPS on rat intestinal and hepatic DC in vivo

Data was obtained on the DC-activating, TLR-4-mediated stimulus, LPS, on rat intestinal and hepatic DC in vivo.

DC present peripheral Ags to T cells in lymph nodes, but also influence their differentiation (tolerance/immunity, Th1/Th2). To investigate how peripheral conditions affect DC properties and might subsequently regulate T cell differentiation, we examined the effects of a potent DC-activating, TLR-4-mediated stimulus, LPS, on rat intestinal and hepatic DC in vivo. Our results suggest that any explanation of switching between tolerance and immunity as well as involving changes in DC activation status must also take into account differential migration of DC subsets.

• stimulus type
• lipopolysaccharide

• organ type
• liver,
• intestine

• cell type
• T cell,
• dendritic cell,
• T helper cell 1,
• T helper cell 2

• organism type
• Rat

• experimental design type
• in vivo design experiment

• experimental factor type
• Organism part factor

created over 15 years ago (2 March 2009)    last modified over 12 years ago (21 May 2012)   [ RDF ]   [ RelFinder ]