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immature dendritic cellThese DC were used in a maturation step for subsequent production of a DC vaccine.
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mature dendritic cellDendritic cells were matured with TNF alpha, IFN gamma and PGE2. These DC were used to produce a DC vaccine.
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dendritic cellThese DC still have functional receptors and are exposed to the receptor antagonist laminarin in order to block them.
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dendritic cellThe receptors of these DC were blocked by addition of laminarin, mannan and chitin.
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monocyteThese monocytes were extracted from a Leukapheresis product from cancer patients using elutriation.
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immature dendritic cellThese DC were generated by culturing enriched monocytes for 5 days.
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regulatory t cellThese Treg were induced after treatment of primed mice with intact anti-CTLA-4 antibodies. These regulatory T cells inhibit Th1 responses, in vitro and in vivo, and repress experimental intestinal inflammation, by a mechanism involving IL-10 and IDO.
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autologous dendritic cellA vaccination trial with RNA transfected autologous DC was done with overlapping peptides covering the whole protein sequence of the tumor antigens MageA3, MelanA and Survivin.
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plasmacytoid dendritic cellThe expression and function of murine FcgammaR in these CD11c+CD11b-B220+ plasmacytoid DCs was investigated.
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dendritic cell...cially available siRNA Smart Pool from Dharmacon targeted against the STAT3 transcription factor have been successfully transfected in these human MDDCs.
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dendritic cellWe have efficiently transfected DC with RNA encoding a functional protein (E/L-Selectin). The mouse E/L-S transfected DC, when given i.v., homed to the lymph nodes, whereas non transfected DC home only to the spleen.
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dendritic cell...tly transfected DC with RNA encoding a functional protein (E/L-Selectin) which allows entry of DC into LN from HEV. The novel adherence capacity of human E/L-S transfected DC was demonstrated via sticking to sialyl-LewisX coated slides using a parallel plate flow microscope. RNA transfected human DC...
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dendritic cellAn HSV vector expressing full length tyrosinase, gp100 and MART-1 was used to transduce DC from melanoma patients which were then to be used for vaccination.
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cellThe cell populations which infiltrate progressive versus regressing P815 mastocytoma were examined in order to identify cells which display immunosuppressive properties. We found changes in regulatory T cells populations as well as in the “myeloid suppressor cells”.
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monocyteThese monocyte come from an elutriation process from a metastatic lesion from stage III/IV melanoma patients and will be used for the generation of a vaccine and generation of tumour-lysated loaded DC.
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dendritic cellThese monocyte-derived dendritic cells are loaded with tumor lysate generated from the excised metastatic lesion of stage III/IV melanoma patients. They will be used for vaccine generation.
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T cellThese T cells stem from an elutriation process from a metastatic lesion of stage III/IV melanoma patients. Subsequently, these T cells will be expanded by co-culture with tumor lysate loaded DC.
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T cellThese T cells were generated from the Leukapheresis product, after elutration, of a metastatic lesion of stage III/IV melanoma patients, expanded by co-culture with tumor lysate loaded DC.
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dendritic cellDC pulsed with tumor antigens were evaluated for their immunotherapy potential in EG7-OVA and P815 tumor models. Depletion of natural regulatory T cells in tumor bearing mice resulted in rejection of P815 cells, but not EG7-OVA, suggesting that regulatory T cells have a stronger impact on immune res...
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myeloid dendritic cellThese DC were matured using CpG-DNA as TLR9 ligand. Mature DCs upregulated CD80, CD86, MHC class II and produced cell type specific cytokines. CD8+ myeloid DCs “cross-presented” exogeneous Ags (Ovalbumin).