Identification of differentially expressed genes by DC after activation with stimuli typically involved in inducing Th1 or Th2 type responses

Global gene expression data have been obtained using Affymetrix mouse chips by designing dendritic cell-based bioassays. To identify possible differentially expressed genes by DC after activation with stimuli typically involved in inducing Th1 or Th2 type responses we have performed comparative kinetic global gene expression analyses of DC activated with different TLR agonists typically associated with Th1 (LPS, CpG, Poly I:C) or Th2 responses (Pam3Cys). For these analyses, we have used the Affymetrix GeneChip® technology and, in particular, mouse chips showing probes for 22690 genes and expressed sequence tags (ESTs).

• stimulus type
• lipopolysaccharide,
• CpG,
• Peptidylglycine alpha-amidating monooxygenase 3 Cys,
• Polyinosinic acid:polycytidylic acid

• molecule type
• Toll like receptor

• cell type
• dendritic cell,
• T helper cell 1,
• T helper cell 2

• organism type
• Mus musculus

• experimental factor type
• Stimulation by cell type factor

• experimental design type
• stimulus or stress response experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]