Comparative pathways-based analysis of genomic and proteomic data from same sourcessignalling dataset
Pathway-level data have been obtained from a pilot experiment on yeast cells treated with peptides with potential antifungal action. We have compared results from both genomics and proteomics experiments and search for similarities at the level of pathways and have used Eu.Gene to compare the two different data sources demonstrating the feasibility of using this program to this task.
Overall correlation between changes in RNA and protein expression was poor but increased when looking at components of immunologically-relevant pathways and Gene ontology terms. The combination of the two sets of results allows selection of the cellular modules acting as hallmarks of dendritic cell maturation from which a molecular signature can be extracted.
- molecule type
- organism type
- Saccharomyces cerevisiae