Small animal model to study the development and function of the human hematopoietic and immune system as well as human specific infections in vivo

We have data available on some functional immune responses in a small animal model to study the development and function of the human hematopoietic and immune system as well as human specific infections in vivo.

We established “human hemato-lymphoid-system mice” by transplanting human CD34+ cord blood cells into irradiated newborn Rag2-/-gc-/- mice, leading to de novo development of human B, T, and dendritic cells; formation of structured primary and secondary lymphoid organs; and production of some limited functional immune responses.

• organism type
• Mus musculus,
• Homo sapiens

• molecule type
• RAG2,
• CD34

• organ type
• organ,
• spinal cord

• bodily part type
• Blood

• cell type
• T cell,
• B cell,
• dendritic cell

• experimental design type
• in vivo design experiment

• experimental factor type
• Genotype factor

created over 15 years ago (2 March 2009)    last modified over 12 years ago (19 December 2011)   [ RDF ]   [ RelFinder ]