Phenotype and function of myeloid derived suppressor cells in ovarian cancer

Currently there is no knowledge about the relevance of MDSC in ovarian cancer patients. However, it is known that both Tregs and suppressive macrophages are increased in this malignancy and have been suggested to correlate with worse prognosis.

In order to obtain data, we are collecting blood and ascitic fluid of ovarian cancer patients to study the presence of immature myeloid populations as compared to healthy donor blood. We have identified two candidate populations that will be tested for the ability to suppress T cells. We also aim to characterize these cells phenotypically and will study potential suppressive mechanisms. Collection of material for this project is ongoing.

created over 14 years ago (14 April 2010)    last modified over 11 years ago (8 July 2013)   [ RDF ]   [ RelFinder ]