Mechanisms controlling the generation/activation of GM-DCs

Based on the data we recently reported concerning the role of GM-CSF in regulating human DC differentiation (Conti et al., EJI 2008), we will perform a detailed analysis of mRNA and microRNA expression in immature and TLR ligand-stimulated GM-DCs in order to identify specific mechanisms that control the generation/activation of these cells. Data obtained in this study will become available. Moreover, the role of microRNAs in controlling the switch of GM-CSF-exposed monocyte precursors toward DCs or macrophages will also be investigated.

created over 14 years ago (24 February 2010)    last modified over 11 years ago (3 June 2013)   [ RDF ]   [ RelFinder ]