Characterization of transport of MHC II molecules during human monocyte-derived DC maturation

We obtained data on MHC II transport during human monocyte-derived DC maturation. We have published that the E3-ubiquitin ligase MARCH I is responsible for peptide-loaded MHC II ubiquitination and their subsequent internalization in immature DC.s The ligase MARCH I has been shown to be down-regulated upon activation. (De gassart et al, PNAS 2008).

We will also investigate further the role of the ubiquitin ligases of the MARCH family in antigen processing, in particular we will focus on cross-presentation and CD1a molecule transport.

• organism type
• Homo sapiens

• molecule type
• Major histocompatibility complex class II,
• E3-ubiquitin ligase MARCH I

• cell type
• dendritic cell

created over 15 years ago (9 December 2009)    last modified over 12 years ago (12 November 2012)   [ RDF ]   [ RelFinder ]