has related document
has knowledgeable contact person
Datasets  >  proteomics dataset  >  Characterization of transpo...

Characterization of transport of MHC II molecules during human monocyte-derived DC maturation

proteomics dataset

We obtained data on MHC II transport during human monocyte-derived DC maturation. We have published that the E3-ubiquitin ligase MARCH I is responsible for peptide-loaded MHC II ubiquitination and their subsequent internalization in immature DC.s The ligase MARCH I has been shown to be down-regulated upon activation. (De gassart et al, PNAS 2008).

We will also investigate further the role of the ubiquitin ligases of the MARCH family in antigen processing, in particular we will focus on cross-presentation and CD1a molecule transport.




created over 7 years ago (9 December 2009)    last modified over 5 years ago (12 November 2012)   [ RDF Rdf ]   [ RelFinder Relfinder ]