Roles of DC in scrapie uptake and dissemination

We are continuing our studies of the roles of DC in scrapie uptake and dissemination and have obtained data on intestinal DC subsets all of which can acquire scrapie ME7 form the intestinal lumen and transport it via lymph.

In current studies we are examining the effects of indomethacin-induced small intestinal inflammation on both intestinal DC biology and on scrapie uptake, transport and delivery. We are characterising (in collaboration with Sebastian Amigorena) rat lymph exosomes and will determine if they transport intestinally-delivered scrapie ME7. We are also examining the effects of a schistosome-derived protein on intestinal immune responses, and have shown that oral administration leads to the rapid appearance of cytokines in lymph.

• cell type
• dendritic cell

• organ type
• intestine

• organism type
• Rat,
• Schistosoma

• molecule type
• indomethacin,
• cytokine

created over 16 years ago (2 March 2009)    last modified over 12 years ago (13 August 2012)   [ RDF ]   [ RelFinder ]