Expression and function of murine FcgammaR in CD11c+CD11b-B220+ plasmacytoid DCs (pDCs)

We have further data available on the expression and function of FcgammaR in mice. We had previously shown that conventional DCs express the inhibitory type II FcgammaR and the activatory type I and type III FcgammaRs. Therefore, we next investigated the expression and function of these murine FcgammaR in CD11c+CD11b-B220+ plasmacytoid DCs (pDCs). pDCs express mostly FcgammaRIIB while the expression of FcgammaRI and FcgammaRIII is only detected by RT-PCR at low but significant level. Moreover, the ITAM-containing intracellular chain associated to FcgammaRI and FcgammaRIII is strongly expressed in pDCs as detected by biochemical assay.

• molecule type
• Fc-gamma RI,
• type III FcgammaR (mouse),
• Fcgamma R-II (mouse),
• CD11b

• cell type
• plasmacytoid dendritic cell

• organism type
• Mus musculus

created over 16 years ago (2 March 2009)    last modified over 12 years ago (16 July 2012)   [ RDF ]   [ RelFinder ]