The target of FcgammaRs with the antigen induces the internalization of the IC

Among the battery of cell surface receptors expressed by DCs, the receptor for the Fc portion of IgG (FcgammaRs) recognizes the antibodies coupled to their specific antigens, called immune complexes (IC). We have data available from our demonstration that the target of FcgammaRs with the antigen induces the internalization of the IC, leading to the maturation of CD11c+CD11b+ conventional DCs. These DCs become thus efficient to present antigenic peptides to helper CD4 T cells and cytotoxic CD8 T cells via cross-presentation pathway. This capability might then enhance antitumor immunity in vivo. The cross-presentation pathway is selectively performed by DCs.

• molecule type
• CD8,
• Fc-gamma receptor,
• immunoglobulin G,
• CD4,
• CD11b,
• CD11c

• cell type
• T cell,
• dendritic cell

created over 15 years ago (2 March 2009)    last modified over 12 years ago (16 July 2012)   [ RDF ]   [ RelFinder ]