In vivo mechanisms of action of vaccine adjuvants

We obtained data on priming of an immune response through a series of critical interactions between the cholera toxin (CT) adjuvant and the dendritic cells (DC) of the splenic marginal zone (MZ).

The in vivo mechanisms of action of most vaccine adjuvants are poorly understood. Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect. We demonstrated in mice that a series of critical interactions between the cholera toxin adjuvant and the dendritic cells of the splenic marginal zone lead to effective priming of an immune response. Thus, for the first time, we have followed adjuvant targeting of MZ DC in vivo.

• organism type
• Mus musculus

• cell type
• dendritic cell

• organ type
• human spleen

• molecule type
• cholera toxin

created over 16 years ago (2 March 2009)    last modified over 12 years ago (9 July 2012)   [ RDF ]   [ RelFinder ]