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Promotion of Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice using DC exosomes along with various TLR ligands or cytokines

preclinical study dataset

Data have been obtained on Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice.

We have used DC exosomes along with various TLR ligands or cytokines such as IL-2 or alpha IFN to promote Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice. We demonstrated that only TLR3 and 9 ligation is able to induce CTL priming in vivo. However, exosomes in the absence of adjuvants can induce NK cell activation. DC exosome-mediated NK cell triggering depends upon NKG2D ligands presented on the exosome surface





created over 14 years ago (2 March 2009)    last modified over 11 years ago (2 July 2012)   [ RDF Rdf ]   [ RelFinder Relfinder ]