Promotion of Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice using DC exosomes along with various TLR ligands or cytokines

Data have been obtained on Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice.

We have used DC exosomes along with various TLR ligands or cytokines such as IL-2 or alpha IFN to promote Mart-1 specific T cell priming and/or NK cell triggering in HHD2 mice. We demonstrated that only TLR3 and 9 ligation is able to induce CTL priming in vivo. However, exosomes in the absence of adjuvants can induce NK cell activation. DC exosome-mediated NK cell triggering depends upon NKG2D ligands presented on the exosome surface

• organism type
• Mus musculus

• cell type
• T cell,
• dendritic cell,
• natural killer cell

• cell component type
• extracellular vesicular exosome

• molecule type
• NKG2D,
• Interleukin-2,
• Toll like receptor 3,
• interferon alpha,
• Melan A

created over 15 years ago (2 March 2009)    last modified over 12 years ago (2 July 2012)   [ RDF ]   [ RelFinder ]