Definition of the mode of activation of RIG-I

We have obtained data using electron microscopy to document the production and secretion of tubulovesicular structures by cells overexpressing VSV-G glycoprotein. These tubulovesicular structures contaminate recombinant viral preparations and play an important role in determining their innate activating potential. The protocols used in those studies have been published and expression vectors for GFP-RIG-I have been made available (outside of the DC-THERA Directory).

• molecule type
• retinoid-inducible gene protein,
• NS1

• organism type
• Vesicular stomatitis virus

created over 16 years ago (2 March 2009)    last modified over 12 years ago (18 June 2012)   [ RDF ]   [ RelFinder ]