DC VACCINATION OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

Our laboratory has data on autologous dendritic cells loaded with apoptotic leukemic cells from patients with B-CLL used as vaccine in patients.

In preclinical experiments DC-loaded with apoptotic leukemic cells were shown to induce a strong preferentially Th1 T-cell response. Apoptotic tumor cells were more effective than lysate, RNA and cell hybrids.

A clinical trial has been initiated where autologous dendritic cells are loaded with apoptotic leukemic cells from patients with B-CLL. So far “vaccines” have been produced for six patients. Four patients are enrolled. A strong type I T cell response has been induced. Preliminary data also indicate reduction of circulating tumor cells. No adverse effects have been observed.

• molecule type
• ribonucleic acids

• cell type
• T cell,
• T helper cell 1,
• apoptotic, leukemic cell,
• autologous dendritic cell

• cell component type
• cell lysate

• experimental design type
• in vivo design experiment,
• ex vivo design experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (14 May 2012)   [ RDF ]   [ RelFinder ]