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Study of the correlation between CD8 multiple cell surface markers and functional profiles studied at single cell level

preclinical study dataset

We obtained data from a study of the correlation between CD8 multiple cell surface markers and functional profiles studied at single cell level. For that purpose, we subdivided peripheral CD8 T cells into eleven different cell subtypes based on the association of multiple cell surface markers. In each subtype, we isolated single-cells. In each single cell, we quantified the expression of multiple genes. Moreover, we isolated and studied cells from different normal donors. These results were published in Blood.

We showed that

- this strategy allowed the identification of different subclasses of T cells,
- each of these subclasses were functionally homogeneous at a single cell level, and
- each of these populations was identical in different donors.





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