Study of the correlation between CD8 multiple cell surface markers and functional profiles studied at single cell level

We obtained data from a study of the correlation between CD8 multiple cell surface markers and functional profiles studied at single cell level. For that purpose, we subdivided peripheral CD8 T cells into eleven different cell subtypes based on the association of multiple cell surface markers. In each subtype, we isolated single-cells. In each single cell, we quantified the expression of multiple genes. Moreover, we isolated and studied cells from different normal donors. These results were published in Blood.

We showed that

- this strategy allowed the identification of different subclasses of T cells,
- each of these subclasses were functionally homogeneous at a single cell level, and
- each of these populations was identical in different donors.

• organism type
• Homo sapiens

• molecule type
• CD8

• cell type
• T cell,
• peripheral blood cell

• experimental design type
• ex vivo design experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (2 May 2012)   [ RDF ]   [ RelFinder ]