Transcriptional profiling of mouse macrophages with different stimuli +/- kinase inhibitors

We obtained transcriptomic data by analysing the effect of the inhibition of Src family kinases by the specific inhibitors PP1/2 on the uncoupling cytokine production in DCs stimulated by agonists of several Toll like receptors. Whole transcriptome analysis indicated the transcription factor IRF-8 and 38 other genes including IL-6 as targets of SRC mediated signalling.

• molecule type
• kinase inhibitor PP2,
• Interleukin-6,
• Toll like receptor,
• kinase inhibitor PP1,
• kinase,
• transcription factor IRF-8

• cell type
• dendritic cell,
• macrophage

• organism type
• Mus musculus

• experimental factor type
• kinase inhibitor PP2,
• kinase inhibitor PP1

created over 17 years ago (2 March 2009)    last modified over 14 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]