Infection of human Hemato-Lymphoid System Rag2-/-gc-/- mice with EBV

Our lab has immunological data available on human Hemato-Lymphoid System Rag2-/-gc-/- mice infected with EBV.

Both Epstein Bar Virus (EBV) and Human Immunodeficiency Virus (HIV) are human specific lymphotropic viruses. Human Hemato-Lymphoid System Rag2-/-gc-/- mice were infected with EBV and mount an immune response (i.e. cytotoxic T cell proliferation, some control of EBV driven B cell proliferation, perforine and granzyme expressing T cell infiltration in B cell infected areas in lymphoid organs in situ), however, specific T cells could not be detected directly ex vivo by looking at the most common EBV derived/presented epitopes (tetramer staining). Some animals developed EBV induced B cell lymphoproliferative disease. All types of B-cell proliferation (polyclonal, oligoclonal, monoclonal) were observed, reflecting B cell proliferation incuced in immuno-suppressed human beings.

• organism type
• Mus musculus,
• Epstein Barr virus

• cell type
• B cell,
• cytotoxic T lymphocyte

• molecule type
• perforin gene,
• granzyme,
• RAG2

• experimental factor type
• Genotype factor

created over 16 years ago (2 March 2009)    last modified over 13 years ago (23 January 2012)   [ RDF ]   [ RelFinder ]