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Identification of versatile central memory CD8+ T-cells capable of high IL-2 secretion

preclinical study dataset

We obtained data from our activity to establish the identification of versatile central memory CD8+ T-cells capable of high IL-2 secretion according to new markers. Versatile human CD8+ T-cells represent up to 30% of the CD8+ central memory pool in healthy adults and are characterised by unique functional capabilities (ability to secrete IL-2 after restimulation in concordance with low effector cytokine (e.g. IFN) and lack of cytotoxic mediator (e.g. perforin) expression (Frentsch et al., unpublished)). They might present an attractive candidate memory/effector CD8+ T-cells to be induced in treatments based on dendritic cell priming.





created over 12 years ago (2 March 2009)    last modified over 9 years ago (21 November 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]