Identification of versatile central memory CD8+ T-cells capable of high IL-2 secretion

We obtained data from our activity to establish the identification of versatile central memory CD8+ T-cells capable of high IL-2 secretion according to new markers. Versatile human CD8+ T-cells represent up to 30% of the CD8+ central memory pool in healthy adults and are characterised by unique functional capabilities (ability to secrete IL-2 after restimulation in concordance with low effector cytokine (e.g. IFN) and lack of cytotoxic mediator (e.g. perforin) expression (Frentsch et al., unpublished)). They might present an attractive candidate memory/effector CD8+ T-cells to be induced in treatments based on dendritic cell priming.

• cell type
• dendritic cell,
• cytotoxic T lymphocyte,
• memory T cell,
• effector T cell

• molecule type
• CD8,
• Interleukin-2

• organism type
• Homo sapiens

• experimental design type
• cell type comparison experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (21 November 2011)   [ RDF ]   [ RelFinder ]