Interaction of MAMPs with TLRs expressed on dendritic cells (DCs)

Data is available on the interaction between microorganism-associated molecular patterns and individual toll-like receptors on dendritic cells that turn on signal transduction pathways leading to the activation of different transcription factors.

Microbial invasions are perceived by pattern recognition receptor (PRR)-expressing cells of the innate immune system. PRRs bind a number of microbial products collectively referred to as microorganism-associated molecular patterns (MAMPs). Toll-like receptors (TLRs) are the best-characterized PRRs. The interaction of MAMPs with TLRs expressed on dendritic cells (DCs) plays a particularly important role in regulation of immune responses. By interacting with different combinations of adapter proteins, individual TLRs turn on signal transduction pathways leading to the activation of different transcription factors, such as nuclear factor (NF)-kB, activation protein (AP)-1, and interferon regulatory factors (IRFs).

• molecule type
• Toll like receptor,
• Nuclear factor NF-kappa B,
• Interferon-regulating factor function,
• Activator protein AP1 human

• cell type
• dendritic cell

• experimental design type
• in vitro design experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (3 October 2011)   [ RDF ]   [ RelFinder ]