Balb-neuT mice model to study new strategies of DC-based and other therapies for advanced breast cancer

Data has been obtained from a Balb-neuT mice model to study new strategies for advanced breast cancer. A colony has been established of transgenic Balb-neuT mice (founders provided by Forni, Torino IT) that over-express the rat HER-2/neu oncogene under the MMTV promoter. These mice develop mammary carcinomas with later lung and liver metastases; the course of disease and the type of tumours that develop closely recapitulate many features of human breast cancer. A collaborative study has commenced between Austyn and Cerundolo to use this model to study new strategies of DC-based and other therapies for advanced breast cancer and for which funding has now been secured for 3y from MRC UK. [A postdoctoral scientist was recruited for this Project from an Associated Partner – Josien, Nantes FR – via the DC-THERA website]

• organ type
• mammary glands,
• lung,
• liver

• molecule type
• HER-2

• cell type
• dendritic cell

• organism type
• Mus musculus,
• Mouse Mammary Tumor Virus

• experimental design type
• in vivo design experiment

created over 16 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]