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Balb-neuT mice model to study new strategies of DC-based and other therapies for advanced breast cancer

preclinical study dataset

Data has been obtained from a Balb-neuT mice model to study new strategies for advanced breast cancer. A colony has been established of transgenic Balb-neuT mice (founders provided by Forni, Torino IT) that over-express the rat HER-2/neu oncogene under the MMTV promoter. These mice develop mammary carcinomas with later lung and liver metastases; the course of disease and the type of tumours that develop closely recapitulate many features of human breast cancer. A collaborative study has commenced between Austyn and Cerundolo to use this model to study new strategies of DC-based and other therapies for advanced breast cancer and for which funding has now been secured for 3y from MRC UK. [A postdoctoral scientist was recruited for this Project from an Associated Partner – Josien, Nantes FR – via the DC-THERA website]






created over 8 years ago (2 March 2009)    last modified over 6 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]