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Recombinant protein generated from Japanin gene

protein

A long-standing collaboration with Centre for Ecology & Hydrology (CEH, UK) has led to the identification of an activity in salivary gland extracts of the tick Rhipicephalus appendiculatus that profoundly modulates the responses of human monocyte-DC towards extrinsic stimuli.

Recombinant protein has been generated from the gene for this molecule (Japanin) which had been cloned. This material inhibits the up-regulation of costimulatory molecules in response to certain TLR agonists, and some cytokines but not others, and modulates the function of the DC in ‘in vitro’ assays. A patent was filed by CEH in September 2008 with Austyn named as inventor relating to the potential use of Japanin as a DC modulator for human therapy.

created over 14 years ago (22 February 2010)    last modified over 12 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]