OVA-loaded DC

We have analyzed the uptake, conservation and cross-presentation of the model antigen OVA after Fc receptor-mediated uptake by DC. We found that MHC class I presentation is relatively short-lived in contrast to MHC class II. However, CD8 cross-priming capacity of OVA-loaded DC was functionally retained for many days, while peptide-pulsed DC had lost their priming capacity after 24 hours.

created over 17 years ago (2 March 2009)    last modified over 14 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]