CCR6-KO mice

We found that CCR6–deficient (CCR6-KO) mice were resistant to induction of EAE but became susceptible when transferred with small number of CCR6-sufficient T cells. CCR6 was found to be required on a first wave of TH-17 cells that entered the CNS through the choroid plexus epithelial cells, which constitutively expressed CCL20 in both mice and humans.

• molecule type
• Th17 cell,
• chemokine receptor CCR6,
• C-C motif chemokine 20

created over 14 years ago (14 December 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]