p50 NF-kB deficient mice

Tumor growth is supported by tumor stroma, such as tumor associated macrophages (TAM) and tumor associated dendritic cells (TADC). We have recently reported that TAM display massive nuclear localization of the p50 NF-kB inhibitory homodimer, which correlates with impaired inflammatory functions.The functional significance of this observation was demonstrated in p50 NF-kB deficient mice, which displayed tumor growth inhibition.

created over 15 years ago (10 December 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]