DCs loaded with Ag-IgG immune complexes (ICs)

DCs pre-loaded in vitro with ICs are at least 1000-fold more potent than ICs injected directly into mice or DCs loaded with the same amount of non-complexed protein. FcgammaRs on DCs were required for efficient priming of Ag-specific CD8+ cells in vivo and induction of tumor protection.

created over 16 years ago (26 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]