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DC-derived exosomes

extracellular vesicular exosome

We showed that, in the absence of adjuvants, DEX mediate potent antigen dependent-antitumor effects against preestablished tumors in mice pretreated with immunopotentiating dosing of cyclophosphamide (CTX). CTX could

i) abolish the suppressive function of CD4+CD25+Foxp3+ regulatory T cells (Treg),
ii) markedly enhance the magnitude of secondary but not primary CTL responsesinduced by DEX vaccines,
iii) synergize with DEX in therapy but not prophylaxis tumor models.

created over 8 years ago (26 March 2009)    last modified over 5 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]