DC-derived exosomes

We showed that, in the absence of adjuvants, DEX mediate potent antigen dependent-antitumor effects against preestablished tumors in mice pretreated with immunopotentiating dosing of cyclophosphamide (CTX). CTX could

i) abolish the suppressive function of CD4+CD25+Foxp3+ regulatory T cells (Treg),
ii) markedly enhance the magnitude of secondary but not primary CTL responsesinduced by DEX vaccines,
iii) synergize with DEX in therapy but not prophylaxis tumor models.

created over 16 years ago (26 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]