DC-derived exosomesextracellular vesicular exosome
We showed that, in the absence of adjuvants, DEX mediate potent antigen dependent-antitumor effects against preestablished tumors in mice pretreated with immunopotentiating dosing of cyclophosphamide (CTX). CTX could
i) abolish the suppressive function of CD4+CD25+Foxp3+ regulatory T cells (Treg),
ii) markedly enhance the magnitude of secondary but not primary CTL responsesinduced by DEX vaccines,
iii) synergize with DEX in therapy but not prophylaxis tumor models.