C57BL/6 mice

We found that the cooperation between IFNalpha,beta and Flt3L (FL) plays an important role in the defense against Herpes simplex virus type 1 (HSV-1) in neonates. Treatment of neonatal mice with recombinant IFNalpha has a short-term, FL-independent and a long-term, FL-dependent protective effect against HSV-1. In mice lacking FL, neonatal resistance against HSV-1 is very low and DC numbers in the spleen are reduced.

In C57BL/6 mice, treatment with rIFNalpha at birth induced both FL and plasmacytoid DC (pDC) that resulted in enhanced resistance against HSV-1 at day 7. In contrast, in mice lacking FL, IFNalpha treatment at birth did not influence splenic cell composition and had no effect on viral protection. The transfer of pDC to mice lacking FL enhanced viral resistance.

created over 15 years ago (19 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]