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iNKT TCR

T cell receptor

We analysed the ability of invariant NKT (iNKT) cells to assist priming of antigen specific T and B cell responses.

1) We have demonstrated that activation of human DC by Toll like receptor ligands (TLR-L) modulates the lipid biosynthetic pathway, resulting in enhanced recognition of CD1d-associated lipids by iNKT cells.

2) We have clarified the mechanisms by which CD1d-restricted lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads into distinct biological responses. Using a soluble iNKT TCR and a newly engineered antibody specific for alpha-galactosylceramide (alpha-GalCer)-human CD1d (hCD1d) complexes, we measured the affinity of binding of iNKT TCR to hCD1d molecules loaded with a panel of alpha-GalCer analogues and assessed the rate of dissociation of alpha-GalCer and alpha-GalCer analogues from hCD1d molecules.

3) We demonstrated that pathogen-derived signals to DC mediated via TLRs can be modulated by activated iNKT cells

created over 12 years ago (2 March 2009)    last modified over 9 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]