G4 patient (E507)

This patient has received 6 vaccines with peptide only in a randomized trial to receive immunizations either with I3 DC (DC generated with interferon-beta and interleukin-3) or with G4 DC (DC generated with GM-CSF and IL-4).

The patient received a sequence of six immunizations every two weeks, consisting of autologous dendritic cells loaded with the 8 HLA-A2 restricted peptides and MAGE.3-DP4 in Cycle 1. In Cycle 2, the patient received a sequence of three immunizations every six weeks, consisting of autologous dendritic cells loaded with the 8 HLA-A2 restricted peptides and MAGE.3-DP4. The patient had clinically shown Partial Response at the end of cycle 1 and was in complete remission in the course of cycle 3.

No immunological response to the vaccinations had been observed after cycle 1 and a new analysis on PBL collected after cycle 2 did not show any change.

• cell type
• autologous dendritic cell

• molecule type
• peptide,
• Granulocyte macrophage colony-stimulating factor,
• Interleukin-4

created over 15 years ago (2 March 2009)    last modified over 13 years ago (28 September 2011)   [ RDF ]   [ RelFinder ]