The gene gun system available to the laboratory was used, e.g., for micro-particle bombardment of murine skin.

We have expertise in DNA vaccination with the gene-gun available to us to directly transfect skin DC in vivo either with expression plasmids or siRNA plasmids to knockdown target genes and follow the effect on the resulting T cell response.

This gene gun was used for the delivery of vectors engineered to express distinct chemokines at the local skin site of mice.