King's College London School of Medicine

AP102

The Department of Medical and Molecular Genetics occupies 3 floors of Guy’s Tower which are currently undergoing total refurbishment into state-of-the art laboratories and IT facilities through a Wellcome Trust JIF/SRIF award, and also supported by the Guy’s and St Thomas’ Charity. Closely associated with, and embedded within, the Department are the NHS clinical diagnostic laboratories and the SE Thames clinical genetics service.

Over the last five years the emphasis of our research has shifted from mapping of Mendelian disease-related genes towards functional genomics and cell and molecular biology, in areas including cancer genetics, neurogenetics, the control of gene expression and epigenetics. We have the necessary expertise and instrumentation (eg microarray expression analysis, bioinformatics, confocal microscopy), and have established a high-throughput genomics and proteomics facility (in collaboration with the Dental Institute).

Diseases on which we are working at a cellular, functional level include; breast cancer, leukaemia, Fanconi anaemia, Huntington’s disease, various developmental anomalies, the muscular dystrophies, and osteopetrosis.

Persons:

• Vuk Cerovic
  DC researcher
• Frank Nestle
  Scientific responsible

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• Phone: +44 20 7188 3713
• Fax: +44 020 7188 2585
• Email: ellen.solomon@kcl.ac.uk
• http://www.kcl.ac.uk/schools/medicine/research/genetics/

• Guy's, King's College & St Thomas' Hospitals
  Floor 8 Guy’s Tower, Guy’s Hospital
  SE1 9RT London
  United Kingdom