L-selectin-negative CCR7- effector and memory CD8+ T cells enter into reactive lymph nodes and kill dendritic cells.

Guarda G., Hons M., Soriano S.F., Huang H.Y., Polley R., Martín-Fontecha A., Stein J.V., Germain R.N., Lanzavecchia A., Sallusto F.
Nat Immunol 2007, 8:743-752.

T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph nodes draining sites of mature dendritic cells or adjuvant inoculation recruited L-selectin-negative CCR7- effector and memory CD8+ T cells. This recruitment required CXCR3 expression on T cells and occurred through high endothelial venules in concert with lumenal expression of the CXCR3 ligand CXCL9. In reactive lymph nodes, recruited T cells established stable interactions with and killed antigen-bearing dendritic cells, limiting the ability of these dendritic cells to activate naive CD4+ and CD8+ T cells. The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses.

URL: http://www.nature.com/ni/journal/v8/n7/abs/ni1469.html

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/17529983

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