Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses.

Hugues S., Scholer A, Boissonnas A, Nussbaum A, Combadiere C, Amigorena S, Fetler L.
Nat. Immunol.. 2007 Sep; 8(9):921-30

Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in search of cognate complexes of peptide in major histocompatibility molecules. However, T cell migration ceases after recognition of cognate antigen. We show here that during the initiation of antigen-specific CD8(+) T cell responses, naive CD8(+) polyclonal T cells 'preferentially' interacted in an antigen-independent way with mature dendritic cells competent to present antigen to antigen-specific CD8(+) T cells. These antigen-independent interactions required expression of the chemokine receptor CCR5 on polyclonal T cells and increased the efficiency of the induction of naive, low-precursor-frequency CD8(+) T cell responses. Thus, antigen-specific CD8(+) T cells favor the priming of naive CD8(+) T cells by promoting the CCR5-dependent recruitment of polyclonal CD8(+) T cells to mature dendritic cells.

URL: http://www.nature.com/ni/journal/v8/n9/abs/ni1495.html

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/17660821

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