The future of cancer vaccines for non-small-cell lung cancer: ongoing trials.

Choudhury A, Palma M, Mellstedt H.
Clin Lung Cancer. 2008 Feb;9 Suppl 1:S37-44.

Lung cancer represents one of the malignancies in which the 3 elements of conventional therapy (ie, surgery, radiotherapy, and chemotherapy) have limited effectiveness in curbing progressive disease. In this context, there is burgeoning interest in the use of vaccine therapy as a nontoxic adjunct to increase the treatment success rates over those obtained with traditional regimens alone. Several clinical trials using a variety of vaccination strategies have been reported or are ongoing. In this review, we have provided an overview of these trials, with a special focus on the clinical efficacy of the vaccines. The future prospects and challenges of vaccine therapy in lung cancer have also been discussed.

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/18540533

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