Overcoming immunosuppressive mechanisms

Widén K, Mozaffari F, Choudhury A, Mellstedt H.
Ann Oncol. 2008 Sep;19 Suppl 7:vii241-7.

Clinical trials have demonstrated from time to time that cancer vaccines can elicit effective antitumour cellular immunity that may translate to clinical benefit for cancer patients. Additionally, several monoclonal antibodies currently used for treating cancer patients mediate their effects through mechanisms like antibody-dependent cellular cytotoxicity (ADCC) and therefore rely on an effective immune system. Patients with advanced tumours, however, are known to have aberrations in their immune function. Improving the clinical effectiveness of immunotherapy therefore depends on having a better understanding of the mechanisms and developing novel strategies to overcome tumour-specific immune suppression.

URL: http://annonc.oxfordjournals.org/content/19/suppl_7/vii241.long

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/18790959

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