has knowledgeable contact person
is document about
Documents and Publications  >  report  >  journal article  >  Central role of dendritic c...

Central role of dendritic cells in the regulation and deregulation of immune responses.

journal article

Granucci F, Zanoni I, Ricciardi-Castagnoli P.
Cell Mol Life Sci. 2008 Jun;65(11):1683-97.

Dendritic cells (DCs) play a critical role in orchestrating the innate and adaptive components of the immune system so that appropriate, coordinated responses are mounted against infectious agents. Tissue-resident DCs interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Antigens use PRR activation to instruct DCs for the appropriate priming of natural killer (NK) cells, followed by specific T-cell responses. Due to the central role of DCs in regulating the activation and progression of immune responses, minor imbalances in the feedback control of Toll-like receptor (TLR)-activated cells have been associated with autoimmunity in genetically prone individuals. We review here recent findings on the role of DCs in the priming of innate and adaptive immune responses and the possible involvement of DCs in inducing and maintaining autoimmune reactions.

URL: http://www.springerlink.com/content/y771626483430374/

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/18327662

created over 15 years ago (8 December 2009)    last modified over 13 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]