has knowledgeable contact person
is document about
Documents and Publications  >  report  >  journal article  >  Role of Toll like receptor-...

Role of Toll like receptor-activated dendritic cells in the development of autoimmunity

journal article

Granucci F, Zanoni I.
Front Biosci. 2008 May 1;13:4817-26.

The recognition of microbial stimuli by Toll-like receptors (TLRs) expressed on dendritic cells (DCs) is essential for the regulation of immune responses. DC activation via TLRs leads to the production of proinflammatory cytokines, chemokines and surface molecules that play a key role in the regulation and control of inflammatory reactions and adaptive immunity. Minor imbalances in the feedback control of TLR-activated innate immune cells have been associated with autoimmunity in genetically prone individuals. We review here recent studies indicating how TLR-mediated activation of innate immune cells, including DCs, may be involved in the development and/or maintenance of autoimmune responses in the presence of both endogenous and exogenous ligands.

URL: http://www.bioscience.org/2008/v13/af/3041/fulltext.htm

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/18508547

created over 15 years ago (8 December 2009)    last modified over 13 years ago (28 September 2011)   [ RDF Rdf ]   [ RelFinder Relfinder ]