Harnessing invariant NKT cells in vaccination strategies

Cerundolo V, Silk JD, Masri SH, Salio M.
Nat Rev Immunol. 2009 Jan;9(1):28-38.

To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune responses by harnessing cells of the innate immune system to assist the expansion of antigen-specific B and T cells. In this Review, we discuss the evidence indicating that invariant natural killer T (iNKT) cells can positively modulate dendritic cells and B cells, and that their pharmacological activation in the presence of antigenic proteins can enhance antigen-specific B- and T-cell responses. In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants.

URL: http://www.nature.com/nri/journal/v9/n1/abs/nri2451.html

Pub Med: http://www.ncbi.nlm.nih.gov/pubmed/19079136

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