Alexander Steinkasserer
Person
Draft templates for CTP
Multimers
Draft templates for IMP
Monocyte-derived and cocktail-matured DC electroporated with a combination of RNAs encoding tumor antigens
transfected mouse DC with RNA encoding a functional protein (E/L-selectin)
Melanoma patients
70 patients, DERMA-ER-DC 04 trial
Multicolor flow cytometer
BD FACSCanto II
MPLC assay
CD8 surface markers
CD4 surface markers
CD3 surface markers
CD45RA surface markers
CCR7 surface markers
CD25 surface markers
CD27 surface markers
CD137 surface markers
CD127 surface markers
CD107a functional markers
RNA transfected autologous DC
Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome.
Human monocyte-derived DC
13 melanoma patients
Elispot analysis
Overlapping peptide library technique for monitoring RNA-DC vaccinated patients
cGMP RNA as API for Tri-Mix Trial
Database on clinical trials with DC
PhD SCIENCE REPORT EWA SKOTNICKA: Interplay between Foxp3+ regulatory T cells and CD83+ dendritic cells / soluble CD83
DERMA-ER-DC 04 clinical trial of DC-based therapy of melanoma patients +/- CD40L activation
DERMA-ER-DC 06 trial: RNA-based DC vaccine
Establishment of immunomonitoring vaccination trials with RNA transfected DC by using overlapping peptides covering the whole protein sequence of the tumor antigens / RNAs used
Analysis of the kinetic of the transcriptional profiling of human MoDC treated with IL2 in vitro
Profiling of human monocyte-derived DC
Phase III RNA-DC trial