Anne O'Garra
Person
MTb-antigen specific T cells
macrophages from mice carrying a null mutation in MAP kinase signalling molecule(s)
Th1 cells producing IFN-gamma solely
mice carrying a null mutation in MAP kinase signalling molecule(s)
DC from mice carrying a null mutation in MAP kinase signalling molecule(s)
myeloid and splenic CD8alpha+ DC
myeloid and splenic CD8alpha- DC
Th1 cells producing IFN-gamma and IL-10
Identification of a macrophage-specific chromatin signature in the IL-10 locus.
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.
GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells.
Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta.
stimulated pDC
Purified mouse DC treated with IL10
IL-10 in mice
IL-12 in mice
Signalling adaptor molecule MyD88
Signalling adaptor molecule TRIF
Phosphorothioate CpG DNA
Salmonella minnesota LPS
poly(I:C) (Invivogen Life Technologies)
Dendritic cells and the control of immunity.
Macrophages and myeloid DC, but not plasmacytoid DC, produce IL-10 in response to MyD88- and TRIF- dependent TLR signals, and TLR-independent signals.
Iterative calibration algorithms
MASCOT probability-based scoring
Exponentially modified Protein Abundance Index (emPAI)
Plasmacytoid DC
Flow cytometer
Mycobacterium tuberculosis
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells.
Macrophages from knockout BALB/c and C57BL/6 mice
knockout BALB/c mice
knockout C57BL/6 mice
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.
Ricardo Rajsbaum
PhD SCIENCE REPORT RICARDO RAJSBAUM
Interleukin-10 independent inhibition of interferon-? and Interleukin-12 production by the TPL-2 / ERK signaling pathway in innate immune responses
Transcriptional profiling of mouse macrophages with different stimuli +/- kinase inhibitors
Responses to mycobacterium tuberculosis infection
Proteomic analysis/profiling of human dendritic cells
Role of certain MAP kinases in the regulation of IL-10 and IL-12, IFN-gamma production
Activation of mouse DC: induction of endogenous IL-10 production by DC subsets accounts for their low levels of IL-12p70 production
Mechanisms for DC-induced Th1 development and the molecular pathways for inducing Th1 cells producing IFN-gamma / IL 10
Identification of specific regulatory elements in the IL-10 locus. Dependence of IL-10 as well as IL-12 production on signalling adaptor molecules
Relative contribution of plasmacytoid DC during bacterial infections