Melanoma patients vaccinated with peptides
The patients were vaccinated with 4 peptides (MAGE-A3, gp100, NA17 and tyrosinase) presented by HLA-A2.
We measured responses to these peptides injected with Montanide, but did not know whether the Montanide adjuvant was important for these T cell responses. Indeed, melanoma patients may mount spontaneous responses to these antigenic peptides. We therefore injected the same peptides without adjuvant, and no response was observed. We conclude that Montanide had a clear adjuvant effect for the CD8 T cell responses measured against these four peptides.
Biomaterial
Homo sapiens
Pierre Coulie
Thierry Boon
Immuno-monitoring of CD8 T cell responses in melanoma patients vaccinated with peptides plus adjuvant, viral vectors, or peptide-pulsed DC