CX3CR1 GFP mice
CX3CR1 GFP mice, in which bmDC are green fluorescent (GFP), were analyzed according to their bmDC localization. It was found that the cells were organized in unique clusters, mainly located in the endosteum of the BM. These DC co-localize with B cells and these clusters are occupying architecturally definable niches and are reminiscent to the niches that were found in the cranial BM parenchyma.
Biomaterial
Mus musculus
Andreas Radbruch
Steffen Jung
Bone marrow of long bones