We have compiled and evaluated all published information on clinical trials with DC worldwide. Questionnaires to all authors concerning follow-up of their published patients are about to be sent out. This database will be made available for all DC-THERA participants and will serve as a basis for a critical report on the role of DC based immunotherapy in cancer 2009.

We have been developing the DC-ATLAS DC-pathway database. For this, we have set about identifying key signalling pathways that were likely to be of most relevance to dendritic cell functions. We have designed a DC-ATLAS data model to effectively describe pathways, their genes, and their interaction. We produced a controlled vocabulary that contains at least 400 ontological terms, prepared on the basis of the proposals and discussions among the researchers involved in DC-ATLAS project. We defined the pathway representation where each pathway was described using three ...

The experiments on human monocyte-derived DC are being annotated in DC-BASE, a unique DC-dedicated database integrated with data mining tools. The database uses a LIMS system based on the structure of Base2.9. The database currently contains 240 microarray experiments annotated accordingly to MIAME standards and thoroughly analyzed in order to pass severe quality control tests. A meeting will be organized for defining policies on data sharing within the DC-THERA community and beyond. In order to populate DC-BASE with data obtained from the literature, we used the ...

The Genopolis microarray database serves as an easy interface for the data generated by the Affymetrix GeneChip platform. DC transcriptomic data produced in the past 4 years has made been an accessible resource for data sharing and data integration accessible to all the DC community. The experiments on mice and rat are currently being annotated and conserved in the Genopolis database. Direct access to the primary data held in the Biopolo database is responsibility of the BIOPOLO Project Management System (see http://www.biopolo.it/).

Mass spectrometry (MS)-based proteomics has become a powerful technology to map the protein composition of organelles, cell types and tissues. In our department, a large-scale effort to map these proteomes is complemented by the Max-Planck Unified (MAPU) proteome database. MAPU contains several body fluid proteomes; including plasma, urine, and cerebrospinal fluid. Cell lines have been mapped to a depth of several thousand proteins and the red blood cell proteome has also been analyzed in depth. The liver proteome is represented with 3200 proteins. By employing hi...